Research groups


STEIN AERTS LAB
Laboratory of computational biology


WIM ANNAERT LAB
Laboratory for membrane trafficking


LUCÍA CHÁVEZ GUTIÉRREZ LAB
Laboratory of proteolytic mechanisms mediating neurodegeneration


SANDRINE DA CRUZ LAB
Laboratory of neurodegenerative disorders and neurophysiology


BART DE STROOPER LAB
Laboratory for the research of neurodegenerative diseases


JORIS DE WIT LAB
Laboratory of synapse biology


ROSE GOODCHILD LAB
Laboratory for dystonia research


NATALIA GUNKO LAB
Electron Microscopy expertise unit


MATTHEW HOLT LAB
Laboratory of glia biology


LYNETTE LIM LAB
Laboratory of interneuron developmental dynamics


ADRIAN LISTON LAB
Translational immunology laboratory


SHA LIU LAB
Laboratory of Sleep and Synaptic Plasticity


SEBASTIAN MUNCK LAB
Light Microscopy expertise unit


FRANCK POLLEUX LAB
Circuit development, maintenance and evolution


DIETMAR SCHMUCKER LAB
Neuronal wiring laboratory


SWITCH LAB
Frederic Rousseau & Joost Schymkowitz


LUDO VAN DEN BOSCH LAB
Laboratory of neurobiology


PIERRE VANDERHAEGHEN LAB
Stem cell and developmental neurobiology


PATRIK VERSTREKEN LAB
Laboratory of neuronal communication


THOMAS VOETS LAB
Laboratory of ion channel research

Lynette Lim

Laboratory of interneuron developmental dynamics

Starting Jan 1st 2020

Information processing in the brain depends on specialized circuits that are formed by distinct types of neurons. How these different nerve cells emerge and mature during development remains a fundamental question in neurobiology.

The Lim lab studies the metabolic and transcriptomic programmes that shape neuronal diversity and circuit assembly in the developing mammalian cortex.

 

Contact

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Sandrine Da Cruz

Laboratory of neurodegenerative disorders and neurophysiology

Starting Oct 1st 2019

The Da Cruz lab studies the spreading of RNA binding proteins, including FUS and TDP-43, in ALS as well as the role of local axonal translation in neurodegeneration in ALS and FTD. The team also focuses on muscle innervation and the development of new therapeutic targets to treat neuromuscular disorders including ALS.

 

Contact

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Franck Polleux

Circuit development, maintenance and evolution

Our research provides new insights into the cellular and molecular mechanisms underlying the establishment and maintenance of brain connectivity and has significant implications for our understanding of the pathophysiological mechanisms underlying socially-devastating neurodevelopmental disorders and neurodegenerative diseases.

Franck Polleux is a visiting PI at our center in 2019. He leads a lab located at the Department of Neuroscience of Columbia University in and the Zuckerman Mind Brain Behavior Institute.

Contact

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Thomas Voets

Laboratory of ion channel research

Our research team focuses on a superfamily of cation channels, the transient receptor potential (TRP) channels,
which includes 27 human members. There is a striking diversity in the stimuli that can regulate the gating of the
TRP channels, which include physical stimuli such as temperature and voltage, as well as various endogenous
and exogenous chemical ligands.

 

Contact

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Patrik Verstreken

Laboratory of neuronal communication

How does the nervous system transmit electrical pulses between neurons, and how is this process affected in neuronal disease?
While considerable progress has been made in identifying proteins present at the synapse, the role of many of them in
controlling synaptic vesicle fusion, vesicle reformation at the plasma membrane and trafficking within the nerve terminal
remain poorly defined. We address these questions using fruit flies as a model.

Patrik Verstreken is the director of our research center.

Contact

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Pierre Vanderhaeghen

Stem cell and developmental neurobiology

The major research goal in our laboratory is to understand the molecular and cellular mechanisms underlying
the development and evolution of the cerebral cortex, from stem cells to neuronal circuits, from mouse to man,
in health and disease.

 

Contact

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Ludo Van Den Bosch

Laboratory of neurobiology

Our research focuses on the mechanisms of acute and chronic axonal and neuronal degeneration and regeneration, aiming to contribute to the development of new therapeutic strategies for neurodegenerative disorders.

We intensively study motor neuron diseases (amyotrophic lateral sclerosis (ALS) and hereditary motor neuropathies), frontotemporal dementia (FTD) and stroke.

Contact

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SWITCH lab

Frederic Rousseau & Joost Schymkowitz

Our research is focused on understanding the mechanisms gearing protein folding and misfolding and their relation to human disease.

In particular we are investigating how protein aggregation affects the interactome by suppressing native interactions but also by introducing novel aggregation-specific interactions.

The latter are especially relevant as they are are usually associated to gain of function activities such as neurotoxicity (neurodegeneration) or cell proliferation (cancer).

 

Contact Frederic Rousseau - Contact Joost Schymkowitz

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Dietmar Schmucker

Neuronal wiring laboratory

Our research is focused on studying the molecular mechanisms of neuronal wiring and the specificity of
molecular recognition processes mediated by membrane receptors

 

Contact

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Sebastian Munck

Light microscopy expertise unit

Our research focuses on the biophysical properties of cell signaling, concerning both the dynamical changes over time and the spatial location of cell signals.

 

Contact

Visit VIB webpage - Expertise unit information

Sha Liu

Laboratory of Sleep and Synaptic Plasticity

Sleep is a fundamental and evolutionarily conserved behavior, and the only major behavior for which the function
remains unknown. The goal of our lab is to understand the synaptic and circuit mechanisms underlying sleep and
its function in the brain.

 

Contact

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Adrian Liston

Translational immunology laboratory

We have two major research divisions: discovery immunology and applied immunology.

  • Discovery Immunology focuses on unravelling more of the basic biology of the immune system, with an emphasis on regulatory T cells and the process of diabetes.
  • Applied Immunology focuses on the human immune system, containing our immune phenotyping platform and gene discovery program.

 

Contact

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Matthew Holt

Laboratory of glia biology

Astrocytes are the most abundant cell type in the mammalian central nervous system. In fact over 60% of the
human brain is composed of astrocytes! Unfortunately, while we know that astrocytes are intimately associated
with neuronal cell bodies and synapses their function(s) remain largely unknown. The long-term goal of our
group is to understand the molecular mechanisms that control development and function of astrocytes in vivo,
and how they interact with neurons.

Contact

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Natalia Gunko

Electron microscopy expertise unit

We facilitate ultrastructural imaging of biological samples as a service to the research community and provide
individual training in scanning and transmission electron microscopy and in sample preparation.

Our own research is focused on neuronal plasticity.

Contact

Visit VIB webpage - Expertise unit information

Rose Goodchild

Laboratory for dystonia research

We investigate the pathophysiology of dystonia; an incapacitating neurological movement disorder of poorly
understood origin. Dystonia is characterized by abnormal involuntary twisting movements that are debilitating
and disabling. Few treatment options are available for patients with dystonia, even though this is a chronic and
permanent condition.

Contact

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Joris de Wit

Laboratory of synapse biology

Our brain is made up of billions of neurons that are precisely connected into neural circuits, forming an immensely
complex network that encodes our thoughts, memories and personalities. Our lab aims to unravel the molecular
mechanisms that control neuronal connectivity in developing circuits, and determine how perturbations in this
process affect cognitive function.

Joris de Wit is vice director of our research center.

Contact

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Bart De Strooper

Laboratory for the research of neurodegenerative diseases

We investigate the basic mechanisms causing Alzheimer’s disease and Parkinson’s disease starting from the genetic forms of these disorders.

 

Contact

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Lucía Chávez-Gutiérrez

Laboratory of proteolytic mechanisms mediating neurodegeneration

We are interested in generating a quantitative understanding of the molecular mechanisms
underlying Alzheimer’s disease pathogenicity.

Our research is based on the premise that getting a better mechanistic understanding of the function
of the molecules involved in familial Alzheimer’s disease (FAD) will offer critical insights into the molecular
basis of the disease and open new research avenues leading to innovative and safe strategies to
tackle the disease in the clinic.

Contact

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Wim Annaert

Laboratory for membrane trafficking

Our laboratory is focused on understanding the molecular biology of membrane transport in a disease-related context covering Alzheimer’s disease and congenital disorders of glycosylation type II.

Contact

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Stein Aerts

Lab of computational biology

We are interested in decoding the genomic regulatory code and understanding how genomic regulatory programs drive
dynamic changes in cellular states, both in normal and disease processes.
Transcriptional states emerge from complex gene regulatory networks. The nodes in these networks are cis-regulatory
regions such as enhancers and promoters, where usually multiple transcription factors bind to regulate the expression
of their target genes.

Contact

Visit VIB webpage  -  Visit the lab's own website

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