Publications

2019 

  1. Vig S, Buitinga M, Rondas D, Crèvecoeur I, van Zandvoort M, Waelkens E, Eizirik DL, Gysemans C, Baatsen P, Mathieu C, Overbergh L. Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells. Cell Death Dis. 2019 Apr 5;10(4):309. doi: 10.1038/s41419-019-1518-0. PubMed PMID: 30952835.
  2. Liesenborghs L, Meyers S, Lox M, Criel M, Claes J, Peetermans M, Trenson S, Vande Velde G, Vanden Berghe P, Baatsen P, Missiakas D, Schneewind O, Peetermans WE, Hoylaerts MF, Vanassche T, Verhamme P. Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves. Eur Heart J. 2019 Mar 3. pii: ehz175. doi: 10.1093/eurheartj/ehz175. [Epub ahead of print] PubMed PMID: 30945735.
  3. Vints K, Vandael D, Baatsen P, Pavie B, Vernaillen F, Corthout N, Rybakin V, Munck S, Gounko NV. Modernization of Golgi staining techniques for high-resolution, 3-dimensional imaging of individual neurons. Scientific Reports. 2019 Jan 15;9(1):130. doi: 10.1038/s41598-018-37377-x. PubMed PMID: 30644431
  4. Boey A, Rybakin V, Kalicharan D, Vints K, Gounko NV. Gold-substituted silver-intensified peroxidase (GSSP) immunolabeling for FIB-SEM imaging. Journal of Histochemistry & Cytochemistry. 2019 Jan 9:22155418824335. doi: 10.1369/0022155418824335. [Epub ahead of print] PubMed PMID: 30624131.
  5. Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lurch G, Serneels L, Navas P, De Strooper B. PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A. 2019 Jan 2. 116(1):277-286. doi: 10.1073/pnas.1811938116. Epub 2018 Dec 21. PubMed PMID: 30578322.

2018 

  1. Van de Vondel E, Baatsen P, Van Elzen R, Lambeir AM, Keiderling TA, Herrebout WA, Johannessen C. Vibrational Circular Dichroism Sheds New Light on the Competitive Effects of Crowding and β-Synuclein on the Fibrillation Process of α-Synuclein. Biochemistry. 2018, Oct 3. doi: 10.1021/acs.biochem.8b00780. [Epub ahead of print] PubMed PMID: 30239196.
  2. Noppe W, Cordier R, Baatsen P, Deckmyn H. Preparation and characterization of large format macroporous cryogel discs for use in affinity chromatography and biotechnological applications. Analytical and Bioanalytical Chemistry. 2018, Oct 3. doi:10.1007/s00216-018-1393-z. [Epub ahead of print] PubMed PMID: 30280230.
  3. Condomitti G, Wierda KD, Rubio SE, Vennekens KM, Orlandi S, Martemyanov KA, Gounko NV, Savas JN, de Wit J. An input-specific orphan receptor GPR158-HSPG interaction organizes hippocampal mossy fiber-CA3 synapses. Neuron. 2018Sep 21. pii: S0896-6273(18)30767-0. doi: 10.1016/j.neuron.2018.08.038.
  4. Lauwers E, Wang YC, Gallardo R, Van der Kant R, Michiels E, Swerts J, Baatsen P, Zaiter SS, McAlpine SR, Gounko NV, Rousseau F, Schymkowitz J, Verstreken P. Hsp90 Mediates Membrane Deformation and Exosome Release. Mol Cell. 2018, Sep 6. 71(5):689-702.e9. doi: 10.1016/j.molcel.2018.07.016. PubMed PMID: 30193096.
  5. Merckx P, De Backer L, Van Hoecke L, Guagliardo R, Echaide M, Baatsen P, Olmeda B, Saelens X, Pérez-Gil J, De Smedt SC, Raemdonck K. Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy. Acta Biomater. 2018, Aug 15. pii: S1742-7061(18)30479-3. doi: 10.1016/j.actbio.2018.08.012. [Epub ahead of print] PubMed PMID: 30118853.
  6. Schroeder A, Vanderlinden J, Vints K, Ribeiro LF, Vennekens KM, Gounko NV, Wierda KD, de Wit J. A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity. Neuron. 2018, Jul 25. 99(2):329-344.e7. doi: 10.1016/j.neuron.2018.06.026. PubMed PMID: 29983322.
  7. Cornelissen T, Vilain S, Vints K, Gounko NV, Verstreken P, Vandenberghe W. Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila. eLife. 2018, May 29. pii: e35878. doi: 10.7554/eLife.35878. PubMed PMID: 29809156; PubMed Central PMCID: PMC6008047.

2017

  1. Guo W, Naujock M, Fumagalli L, Vandoorne T, Baatsen P, Boon R, Patel S, Welters M, Vanwelden T, Geens N, Tricot T, Benoy V, Steyaert J, Lefebvre C, Boesmans W, Jarpe M, Sterneckert J, Wegner F, Petri S, Bohl D, Vanden Berghe P, Robberecht W, Van Damme P, Verfaillie V, Van Den Bosch L. HDAC6 inhibition reverses axonal transport defect in motor neurons derived from ALS patients with FUS mutations. Nature Communications. 2017, Oct 11. 8(1):861. doi: 10.1038/s41467-017-00911-y. PMID: 29021520
  2. Briz V, Restivo L, Pasciuto E, Juczewski K, Mercaldo V, Baatsen P, Gounko NV, Borreca A, Girardi T, Luca R, Nys J, Lo AC, Poorthuis R, Mansevelder H, Fisone G, Ammassari-Teule M, Arckens L, Krieger P, Meredith R, Bagni C. The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning. Nature Communications, 2017, Aug 17. 8(1):293. PMID: 28819097 PMCID: PMC5561022 DOI: 10.1038/s41467-017-00311-2.
  3. Vanhauwaert R, Kuenen S, Masius R, Bademosi A, Manetsberger J, Schoovaerts N, Bounti L, Gontcharenko S, Swerts J, Vilain S, Picillo M, Barone P, Munshi ST, de Vrij FMS, Kushner SA, Gounko NV, Mandemakers W, Bonifati V, Meunier F, Sandra-Fausia Soukup SF, Verstreken P. The Parkinson disease causing mutation in Synaptojanin blocks autophagosome maturation at presynaptic terminals. EMBO J. 2017, May 15. 36(10):1392-1411. doi:10.15252/embj.201695773.
  4. Van der Kant R, Karow-Zwick AR, Van Durme J, Blech M, Gallardo R, Seeliger D, Aßfalg K, Baatsen P, Compernolle G, Gils A, Studts JM, Schulz P, Garidel P, Schymkowitz J, Rousseau F. Prediction and Reduction of the Aggregation of Monoclonal Antibodies. J Mol Biol. 2017, Apr 21. 429(8):1244-1261. doi:10.1016/j.jmb.2017.03.014. Epub 2017 Mar 18. PubMed PMID: 28322916; PubMed Central PMCID: PMC5397608.
  5. Boeynaems S, Bogaert E, Kovacs D, Volkov A, Guharoy M, Jaspers T, De Decker M, Ryan V, Janke A, Baatsen P, Impens F, Schymkowitz J, Rousseau F, Fawzi N, Robberecht W, Van Damme P, TompaP, Van Den Bosch L. Liquid-liquid phase separation of C9orf72 dipeptide repeats affects RNA granule dynamics. Mol Cell. 2017, Mar 16. 65(6):1044-1055.e5. doi:10.1016/j.molcel.2017.02.013. PubMed PMID: 28306503; PubMed Central PMCID:PMC5364369.
  6. Tharkeshwar AK, Trekker J, Vermeire W, Pauwels J, Sannerud R, Priestman DA, Te Vruchte D, Vints K, Baatsen P, Decuypere JP, Lu H, Martin S, Vangheluwe P, Swinnen JV, Lagae L, Impens F, Platt FM, Gevaert K, Annaert W. A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency. Sci Rep. 2017, Jan 30. 7:41408. doi: 10.1038/srep41408. PubMed PMID: 28134274; PubMed Central PMCID: PMC5278418.

2016

  1. Holvoet P, Vanhaverbeke M, Bloch K, Baatsen P, Sinnaeve P, Janssens S. Low MT-CO1 in Monocytes and Microvesicles Is Associated With Outcome in Patients With Coronary Artery Disease. J Am Heart Assoc. 2016, Dec 5. 5(12). pii: e004207. PubMed PMID: 27919931; PubMed Central PMCID: PMC5210432.
  2. Soukup SF, Kuenen S, Vanhauwaert R, Manetsberger J, Hernández-Díaz S, Swerts J, Schoovaerts N, Vilain S, Gounko NV, Vints K, Geens A, De Strooper B, Verstreken P. A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals. Neuron2016, Nov 23. 92(4):829-844. doi: 10.1016/j.neuron.2016.09.037. PubMed PMID: 27720484.
  3. Riethorst D, Baatsen P, Remijn C, Mitra A, Tack J, Brouwers J, Augustijns P. An In-Depth View into Human Intestinal Fluid Colloids: Intersubject Variability in Relation to Composition. Mol Pharm. 2016, Oct 3. 13(10):3484-3493. PubMed PMID: 27576295.
  4. Grillet M, Dominguez Gonzalez B, Sicart A, Pöttler M, Cascalho A, Billion K, Hernandez Diaz S, Swerts J, Naismith TV, Gounko NV, Verstreken P, Hanson PI, Goodchild RE. Torsins Are Essential Regulators of Cellular Lipid Metabolism. Dev Cell. 2016, Aug 8. 38(3):235-47. doi: 10.1016/j.devcel.2016.06.017. PubMed PMID: 27453503.
  5. Gounko NV, Martens E, Opdenakker G, Rybakin V. Thymocyte development in the absence of matrix metalloproteinase-9/gelatinase B. Sci Rep. 2016, Jul 19. 6:29852. doi: 10.1038/srep29852. PubMed PMID: 27432536; PubMed Central PMCID: PMC4949482.
  6. Stremersch S, Marro M, Pinchasik, Baatsen P, De Smedt SC, Skirtach AG, Loza-Alvarez P, Raemdonck K, Braeckmans K. Identification of Individual Exosome-Like Vesicles by Surface Enhanced Raman Spectroscopy. Small. 2016, Jun 12. (24):3292-301. doi: 10.1002/smll.201600393. PubMed PMID: 27171437.
  7. Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, 5Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, Vints K, Baatsen P, Munck S, Basi GS, Mercken M, Vooijs M, Bollen M, Schymkowitz J, Rousseau F, Bonifacino JS, Van Niel G, De Strooper B, Annaert W. Restricted location of PSEN2 γ-secretase determines substrate specificity and generates an intracellular Aβ pool. Cell. 2016, Jun 30. 166(1):193-208. doi: 10.1016/j.cell.2016.05.020. PubMed PMID: 27293189.
  8. Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DLJ, Gevaert K, Vandesompele J, Mestdagh P,Christophe Marine JC. Melanoma addiction to the long non-coding RNA. Nature. 2016, March 24. 531:518–522. doi: 10.1038/nature17161.
  9. Khodaparast L, Khodaparast L, Shahrooei M, Stijlemans B, Merckx R, Baatsen P, O'Gara JP, Waters E, Van Mellaert L, Van Eldere J. The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation. PLoS One. 2016, Jan 22. 11(1):e0146704. doi: 10.1371/journal.pone.0146704. PubMed PMID: 26799073; PubMed Central PMCID: PMC4723045.
  10. Vasconcelos B, Stancu IC, Buist A, Bird M, Wang P, Vanoosthuyse A, Van Kolen K, Verheyen A, Kienlen-Campard P, Octave JN, Baatsen P, Moechars D, Dewachter I. Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo. Acta Neuropathol. 2016, Apr 13. 1(4):549-69. doi: 10.1007/s00401-015-1525-x. PubMed PMID: 26739002; PubMed Central PMCID: PMC4789256.
  11. Bednarska NG, van Eldere J, Gallardo R, Ganesan A, Ramakers M, Vogel I, Baatsen P, Staes A, Goethals M, Hammarström P, Nilsson KP, Gevaert K, Schymkowitz J, Rousseau F. Protein aggregation as an antibiotic design strategy. Mol Microbiol. 2016, Mar 99(5):849-65. doi: 10.1111/mmi.13269. PubMed PMID: 26559925.
  12. Larsimont JC, Youssef KK, Sánchez-Danés A, Sukumaran V, Defrance M, Delatte B,Liagre M, Baatsen P, Marine JC, Lippens S, Guerin C, Del Marmol V, Vanderwinden JM, Fuks F, Blanpain C. Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion. Cell Stem Cell. 2015, Jul 2. 17(1):60-73. doi: 10.1016/j.stem.2015.05.008. PubMed PMID: 26095047.

2015

  1. De Brucker K, Tan Y, Vints K, De Cremer K, Braem A, Verstraeten N, Michiels J,Vleugels J, Cammue BP, Thevissen K. Fungal β-1,3-glucan increases ofloxacin tolerance of Escherichia coli in a polymicrobial E. coli/Candida albicans biofilm. Antimicrob Agents Chemother. 2015, Mar 9. 59(6):3052-8. doi: 10.1128/AAC.04650-14. PubMed PMID: 25753645; PubMed Central PMCID: PMC4432160.
  2. Stancu IC, Vasconcelos B, Ris L, Wang P, Villers A, Peeraer E, Buist A, Terwel D, Baatsen P, Oyelami T, Pierrot N, Casteels C, Bormans G, Kienlen-Campard P, Octave JN, Moechars D, Dewachter I. Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice. Acta Neuropathol. 2015, Jun ;129(6):875-94. doi: 10.1007/s00401-015-1413-4. PubMed PMID: 25862635; PubMed Central PMCID: PMC4436846.
  3. Claessens J, Roriz M, Merckx R, Baatsen P, Van Mellaert L, Van Eldere J. Inefficacy of vancomycin and teicoplanin in eradicating and killing Staphylococcus epidermidis biofilms in vitro. Int J Antimicrob Agents. 2015, Apr ;45(4):368-75. doi: 10.1016/j.ijantimicag.2014.11.011. PubMed PMID: 25614358.
  4. Arranz AM, Delbroek L, Van Kolen K, Guimarães MR, Mandemakers W, Daneels G, Matta S, Calafate S, Shaban H, Baatsen P, De Bock PJ, Gevaert K, Berghe PV, Verstreken P, De Strooper B, Moechars D. LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism. J Cell Sci. 2015, Feb 1. 128(3):541–52. PubMed PMID: 25501810.
  5. Urwyler O, Izadifar A, Dascenco D, Petrovic M, He H, Ayaz D, Kremer A, Lippens S, Baatsen P, Guérin CJ, Schmucker D. Investigating CNS synaptogenesis at single-synapse resolution by combining reverse genetics with correlative light and electron microscopy. Development. 2015, Jan 15. 142(2):394-405. doi: 10.1242/dev.115071. PubMed PMID: 25503410.
  6. Couceiro JR, Gallardo R, De Smet F, De Baets G, Baatsen P, Annaert W, Roose K, Saelens X, Schymkowitz J, Rousseau F. Sequence-dependent internalization of aggregating peptides. J Biol Chem. 2015, Jan 2. 290(1):242-58. doi: 10.1074/jbc.M114.586636. PubMed PMID: 25391649; PubMed Central PMCID: PMC4281728.

2014

  1. Vangoitsenhoven R, Rondas D, Crèvecoeur I, D'Hertog W, Baatsen P, Masini M, Andjelkovic M, Van Loco J, Matthys C, Mathieu C, Overbergh L, Van der Schueren B. Foodborne cereulide causes beta-cell dysfunction and apoptosis. PLoS One. 2014, Aug 13. 9(8):e104866. doi: 10.1371/journal.pone.0104866. PubMed PMID: 25119564; PubMed Central PMCID: PMC4132018.

2013

  1. Jurisch-Yaksi N, Rose AJ, Lu H, Raemaekers T, Munck S, Baatsen P, Baert V, Vermeire W, Scales SJ, Verleyen D, Vandepoel R, Tylzanowski P, Yaksi E, de Ravel T, Yost HJ, Froyen G, Arrington CB, Annaert W. Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels. J Cell Biol. 2013, Mar 18. 200(6):709-20. doi: 10.1083/jcb.201208175. PubMed PMID: 23479743; PubMed Central PMCID: PMC3601348.

2012

  1. Lieben L, Masuyama R, Torrekens S, Van Looveren R, Schrooten J, Baatsen P, Lafage-Proust MH, Dresselaers T, Feng JQ, Bonewald LF, Meyer MB, Pike JW, Bouillon R, Carmeliet G. Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. J Clin Invest. 2012, May ;122(5):1803-15. doi: 10.1172/JCI45890. PubMed PMID: 22523068; PubMed Central PMCID: PMC3336970.
  2. Raemaekers T, Peric A, Baatsen P, Sannerud R, Declerck I, Baert V, Michiels C, Annaert W. ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation. EMBO J. 2012, Aug 1. 31(15):3252-69. doi: 10.1038/emboj.2012.182. PubMed PMID: 22781129; PubMed Central PMCID: PMC3411082.

2011

  1. Thimiri Govinda Raj DB, Ghesquière B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, De Strooper B, Waelkens E, Borghs G, Callewaert N, Swinnen J, Gevaert K, Annaert W. A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes. Mol Syst Biol. 2011, Oct 25. 7:541. doi: 0.1038/msb.2011.74. PubMedPMID: 22027552; PubMed Central PMCID: PMC3261717.
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