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geen vertaling beschikbaar Alzheimer risk genes converge on microglia

18/03/2020

Our DNA determines a large part of our risk for Alzheimer’s disease, but it remained unclear how many genetic risk factors contribute to disease. A team led by Prof. Bart De Strooper (VIB-KU Leuven) and Dr. Mark Fiers now show that many of those risk factors affect brain maintenance cells called microglia, and more particularly their response to amyloid-beta, one of the proteins aggregating in the brains of Alzheimer patients.