Laboratory of Interneuron Developmental Dynamics
The Lim lab studies the metabolic and transcriptomic programmes that shape neuronal diversity and circuit assembly in the developing mammalian cortex.
Research areas
Neurobiology Cancer Biology Computational biology
Research Focus
The Lim lab studies the metabolic and transcriptomic programmes that shape neuronal diversity and circuit assembly in the developing mammalian cortex.
We are interested to define at single-cell resolution the metabolic and transcriptomic programmes that shape neuronal diversity and circuit assembly in the developing mammalian cortex.
Our research focuses primarily on GABAergic cortical neurons since they are one of the most diverse cell types in the brain and play multifaceted roles in controlling principal pyramidal neurons and fine-tune network computation. We employ an interdisciplinary approach to our work that combines mouse genetics, virus tracing, cell fate-mapping, metabolomics, and single-cell RNA sequencing, with cutting-edge imaging techniques and bioinformatics to define how developmental programmes influence cortical circuit formation.
