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Modulation of TRPA1 by cholesterol CRACked. Read all about Justyna Startek's PhD work in the latest issue of eLife!
New work by the Chávez-Gutiérrez lab on gamma-scretase is out in the EMBO journal.
Our second example of the intense exchange of our basic science researchers with the Discovery Sciences team leads us into the field of neurology and peripheral neuropathies. More specifically to Charcot-Marie-Tooth disease (CMT), an incurable progressive weakening and atrophy of distal limb muscles. Patients develop foot deformities and gait difficulties, and also experience sensory abnormalities. CMT has a severe impact on the quality of life of its patients. Ludo Van Den Bosch, who is specialized in CMT, is professor neurobiology at the VIB-KU Leuven Center for Brain & Disease Research.
An international team of researchers at VIB-KU Leuven, Belgium, the UK Dementia Institute and the Children’s Cancer Institute, Australia, have found a safer treatment for a specific type of leukemia. By refining a therapeutic avenue that was previously abandoned because of its severe side effects, they came up with a targeted approach that was both effective and safe in mice and in human cancer cells.
Europe is a top destination for research. Nature news interviews Sha Liu.
Leuven researchers uncover new mechanisms of brain development that determine when, where and how strongly distinct brain cells interconnect. The brain consists of a large collection of interconnected neurons. How complex patterns of neuronal cells grow into functioning circuits during development has fascinated researchers for decades. A team of scientists at VIB and KU Leuven has now uncovered a new signaling mechanism in fruit flies that specifies the formation of neuronal circuits in the brain.
A Leuven research team led by Prof. Bart De Strooper (VIB-KU Leuven, UK DRI) studied how specialized brain cells called microglia respond to the accumulation of toxic proteins in the brain, a feature typical of Alzheimer’s. The three major disease risk factors for Alzheimer’s—age, sex and genetics—all affect microglia response, raising the possibility that drugs that modulate this response could be useful for treatment.
Nature Methods interviews Stein Aerts about cisTopic and much more.
A Belgian team of computational biologists led by Stein Aerts (VIB-KU Leuven) has developed a new bioinformatics method called cisTopic. Inspired by text-mining methods, cisTopic helps scientists to gain insight into the mechanisms underlying the differences in gene regulation across and within the cells in our body by looking for common topics. In a new publication in Nature Methods, Aerts and his team demonstrate the broad range of applications of this method, from brain research to cancer biology.
The European Research Council (ERC) is unique in its kind in Europe supporting individual top researchers from anywhere in the world for 5 years to embark on an innovative and highly challenging research project. The ERC Program covers all levels of research career and the Advanced Grants are awarded to exceptional leaders in research embarking on a novel high-risk/high gain research line. No less than 5 VIB researchers have been awarded this very competitive and widely acknowledged benchmarks of scientific excellence.