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Targeting drugs to the brain

24/09/2019

According to the World Health Organization (WHO), neurological disorders, ranging from epilepsy to Alzheimer’s disease, affect up to one billion people worldwide. These neurological disorders affect people in all countries, irrespective of age, sex, education, or income. The impact of these conditions on healthcare systems across the globe is enormous, and with an aging population in many countries this burden is likely to increase. Patients do not only experience difficulties in the practicalities of life, but also in their emotional and psychological experiences.

To become, or not to become... a neuron

25/07/2019

Researchers led by Pierre Vanderhaeghen and Jérôme Bonnefont (VIB-KU Leuven and ULB), in collaboration with Stein Aerts (VIB KU Leuven) and François Guillemot (Crick Institute), have unraveled a new mechanism controlling the switch between growth and differentiation of neural stem cells during brain development. They discovered a specific factor that makes stem cells ‘deaf’ to proliferative signals, which in turn causes them to differentiate into neurons and shape the marvelous complexity of our brain.