Laboratory of Neuronal Communication
How does the nervous system transmit electrical pulses between neurons, and how is this process affected in neuronal disease? While considerable progress has been made in identifying proteins present at the synapse, the role of many of them in controlling synaptic vesicle fusion, vesicle reformation at the plasma membrane and trafficking within the nerve terminal remain poorly defined. We address these questions using fruit flies as a model.
We study how the brain operates and how brain function is affected by neurodegenerative diseases, specifically Parkinson’s disease and Tauopathies. We use fruit flies and human neurons for our studies and resort to genetics, biochemistry, electron microscopy, imaging and electrophysiology to analyse neuronal communications and synaptic survival.