Laboratory of Interneuron Developmental Dynamics

The Lim lab studies the metabolic and transcriptomic programmes that shape neuronal diversity and circuit assembly in the developing mammalian cortex. 

Lynette Lim

Group Leader
VIB Group Leader since January 1, 2020
Postdoc: Institute of Neuroscience, Alicante, Spain, 2012-2014
Postdoc: King’s College London, UK, 2014-2019
PhD: National University of Singapore, Singapore, 2007

Research areas

Neurobiology Cancer Biology Computational biology

Research Focus

The Lim lab studies the metabolic and transcriptomic programmes that shape neuronal diversity and circuit assembly in the developing mammalian cortex. 

We are interested to define at single-cell resolution the metabolic and transcriptomic programmes that shape neuronal diversity and circuit assembly in the developing mammalian cortex. 

Our research focuses primarily on GABAergic cortical neurons since they are one of the most diverse cell types in the brain and play multifaceted roles in controlling principal pyramidal neurons and fine-tune network computation. We employ an interdisciplinary approach to our work that combines mouse genetics, virus tracing, cell fate-mapping, metabolomics, and single-cell RNA sequencing, with cutting-edge imaging techniques and bioinformatics to define how developmental programmes influence cortical circuit formation.