Lab of Glia Biology

Astrocytes are the most abundant cell type in the mammalian central nervous system. In fact, over 60% of the human brain is composed of astrocytes! Unfortunately, while we know that astrocytes are intimately associated with neuronal cell bodies and synapses their function(s) remain largely unknown. The long-term goal of our group is to understand the molecular mechanisms that control development and function of astrocytes in vivo, and how they interact with neurons.

Matthew Holt

Group Leader
VIB Group leader since 2012
Postdoc: Max Planck Institute for Biophysical Chemistry, Göttingen, Germany, 2003-2011
Postdoc: MRC Laboratory of Molecular Biology, Cambridge, UK, 2002-2003
PhD: MRC Laboratory of Molecular Biology, Cambridge, UK, 2002

Research focus

The long-term goal of our group is to understand the molecular mechanisms that control development and function of astrocytes in vivo, and how they interact with neurons. Our strategy is to use astrocytes isolated from mouse brain as a starting point. This allows us to effectively take a “bottom up” approach to astrocyte function.

Publications

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Team

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Funding

Past and present research in the Holt lab was possible thanks to the support of the following organizations and foundations:

ERC FWO Hercules foundation KU Leuven Marie Skłodowska-Curie

SAO Thierry Latran Foundation VLAIO