Laboratory of Proteolytic Mechanisms Mediating Neurodegeneration 

The Laboratory of Proteolytic Mechanisms Mediating Neurodegeneration is interested in generating a quantitative understanding of the molecular mechanisms underlying Alzheimer’s disease pathogenicity.

Lucía Chávez Gutiérrez

Group Leader
VIB Group leader since July 2017
Assistant Professor: KU Leuven, Leuven, Belgium, since 2013
Postdoc: VIB-KU Leuven, Leuven, Belgium, 2005-2010
PhD: Natl. Univ. of México, Mexico, 2005

Research focus

Our research is based on the premise that getting a better mechanistic understanding of the function of the molecules involved in familial Alzheimer’s disease (FAD) will offer critical insights into the molecular basis of the disease and open new research avenues leading to innovative and safe strategies to tackle the disease in the clinic.

Genetics has shown that mutations in functionally related genes (Presenilins (PSEN) and Amyloid Precursor Protein (APP)) cause Alzheimer’s disease (AD) with early onset. PSEN is the catalytic subunit of the γ-secretase intramembrane proteases, which sequentially cleave APP to generate Aβ peptides. Alzheimer’s disease-causing mutations consistently lead to production of longer amyloidogenic Aβ peptides and this points at the shift in Aβ length as fundamental to the disease pathogenic mechanism. The mutant-induced changes in Aβ profiles as well as the Aβ-mediated neurotoxicity mechanism are poorly defined. 

We are interested in generating a quantitative understanding of the molecular mechanisms underlying Alzheimer’s disease pathogenicity. Our research is based on the premise that getting a better mechanistic understanding of the function of the molecules involved in familial Alzheimer’s disease (FAD) will offer critical insights into the molecular basis of the disease and open new research avenues leading to innovative and safe strategies to tackle the disease in the clinic. 

Publications

To showcase the world-class scientific research of the Lucía Chavez-Gutiérrez Lab, you can discover their scientific papers in more detail.

More info

Jobs

We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.

More info

Team

The Lucía Chavez-Gutiérrez’ Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.

More info

Events

To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.

More info