Dominique Morneau, chief editor of Nature Reviews Methods Primers, interviewed Liesbeth Minnoye about her experience writing a collaborative paper on chromatin accessibility profiling methods.
Lots of activity in our building these weeks, as the labs located in ON4 are gradually moving to the new ON5 building this January and February.
Congrats to Lynette Lim, Stein Aerts, Sandrine Da Cruz, Matthew Holt and Pierre Vanderhaeghen on obtaining project funding from FWO!
Cancers are extremely heterogeneous. Even within the same tumor, some cells may be more aggressive than others. In the latest issue of Nature Cell Biology, a team of scientists led by Stein Aerts (VIB-KU Leuven Center for Brain & Disease Research) reports how distinct gene regulatory networks drive melanoma skin cancer cells to become more invasive. The findings will inform research into better cancer treatments.
Each year, the European Research Council awards Proof of Concept grants to ERC grant holders who wish to take their ERC research one step further towards application. This year, no less than three VIB principal investigators have received an ERC PoC grant: Prof. Kevin Verstrepen (VIB-KU Leuven Center for Microbiology), Prof. Patrik Verstreken, and Prof. Stein Aerts (both from the VIB-KU Leuven Center for Brain and Disease Research).
Single cell technologies provide unprecedented insights into the dynamics of gene regulation of individual cells, but resolving spatiotemporal regulation networks has remained an experimental and computational challenge. A team of scientists lead by Stein Aerts (VIB-KU Leuven) came up with a new approach to map gene regulation in 2D tissues.
A Belgian team of computational biologists led by Stein Aerts (VIB-KU Leuven) has developed a new bioinformatics method called cisTopic. Inspired by text-mining methods, cisTopic helps scientists to gain insight into the mechanisms underlying the differences in gene regulation across and within the cells in our body by looking for common topics. In a new publication in Nature Methods, Aerts and his team demonstrate the broad range of applications of this method, from brain research to cancer biology.
VIB team maps each individual fly brain cell throughout the aging process. Stein Aerts (VIB-KU Leuven Center for Brain & Disease Research) and his team have accomplished a world first: a gene expression map of every cell within the brain of an aging fly. While fly brains are comparatively simple, consisting of only 100,000 different cells, they are still complex networks that aptly serve as models for the human brain. Thus, the atlas is a key step toward a better understanding of human disease development.
A team of scientists lead by prof. Stein Aerts (VIB-KU Leuven) is the first to map the gene expression of each individual brain cell during aging, though they started small: with the brain of a fruit fly. Their ‘cell atlas’ provides unprecedented insights into the workings of the brain as it ages. Published today in the scientific journal Cell, the atlas is heralded as an important first step in the development of techniques that can help us gain a better understanding of human disease development.
A team led by Prof. Stein Aerts (VIB-KU Leuven) uncovers how access to relevant DNA regions is orchestrated in epithelial cells. These findings shed new light on the biological mechanisms of gene regulation and open up potential new avenues for cellular reprogramming.